Hernandez, M. orcid.org/0000-0003-4474-5883 and Pudney, S. (2016) Copula-based modelling of self-reported health states An application to the use of EQ-5D-3L and EQ-5D-5L in evaluating drug therapies for rheumatic disease. Discussion Paper. HEDS Discussion Paper Series (16.06). Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield , Sheffield.
Abstract
EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument generating a description of health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but there little is known about the consequences of this change. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse the joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people affected by rheumatoid disease, and use it to generate mappings between the 3-level and 5-level descriptive systems. We find significant conflicts between the two, which would imply the reversal of an important conclusion in a real-world evaluation of drug therapies. Keywords: EQ-5D, ordinal response, copula, mixture models, rheumatoid arthritis, mapping, economic evaluation JEL codes: C35, C83, D61, H51, I10
Metadata
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Copyright, Publisher and Additional Information: | © 2016 The Authors. Reproduced in accordance with the publisher's self-archiving policy. | ||||||||
Keywords: | EQ-5D; ordinal response; copula; mixture models; rheumatoid arthritis; mapping; economic evaluation | ||||||||
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Institution: | The University of Sheffield | ||||||||
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science > HEDS Discussion Paper Series | ||||||||
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Depositing User: | Symplectic Sheffield | ||||||||
Date Deposited: | 12 Apr 2016 15:43 | ||||||||
Last Modified: | 12 Apr 2016 16:17 | ||||||||
Published Version: | http://www.sheffield.ac.uk/scharr/sections/heds/di... | ||||||||
Status: | Published | ||||||||
Publisher: | Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield | ||||||||
Series Name: | HEDS Discussion Paper Series | ||||||||
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