Mewar, D., Marinou, I., Timms, J.M., Kilding, R. and Wilson, A.G. (2005) Polymorphism within the telomeric MHC and expression of rheumatoid arthritis candidate genes. In: 25th European Workshop for Rheumatology Research, 24-27 February 2005, Glasgow, UK.
Several recent studies have indicated a second susceptibility locus for rheumatoid arthritis (RA) in the telomeric MHC close to the tumour necrosis factor locus, a region containing a number of genes of unknown function including HLA-B associated transcripts 1 and 2 (BAT1 and BAT2) and lymphotoxin alpha (LTA). Several single-nucleotide polymorphisms have been described in this region; however, the influence of each on susceptibility is not known. In this study we sought to examine the association of individual single-nucleotide polymorphisms with expression of each mRNA transcript in response to an inflammatory stimulus.
|Copyright, Publisher and Additional Information:||© 2005 BioMed Central Ltd|
|Institution:||The University of Sheffield|
|Academic Units:||The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Division of Genomic Medicine (Sheffield)|
|Depositing User:||Sheffield Import|
|Date Deposited:||09 Oct 2009 09:37|
|Last Modified:||09 Oct 2009 09:37|