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Polymorphism within the telomeric MHC and expression of rheumatoid arthritis candidate genes

Mewar, D., Marinou, I., Timms, J.M., Kilding, R. and Wilson, A.G. (2005) Polymorphism within the telomeric MHC and expression of rheumatoid arthritis candidate genes. In: 25th European Workshop for Rheumatology Research, 24-27 February 2005, Glasgow, UK.

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Abstract

Several recent studies have indicated a second susceptibility locus for rheumatoid arthritis (RA) in the telomeric MHC close to the tumour necrosis factor locus, a region containing a number of genes of unknown function including HLA-B associated transcripts 1 and 2 (BAT1 and BAT2) and lymphotoxin alpha (LTA). Several single-nucleotide polymorphisms have been described in this region; however, the influence of each on susceptibility is not known. In this study we sought to examine the association of individual single-nucleotide polymorphisms with expression of each mRNA transcript in response to an inflammatory stimulus.

Item Type: Conference or Workshop Item (Poster)
Copyright, Publisher and Additional Information: © 2005 BioMed Central Ltd
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Division of Genomic Medicine (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 09 Oct 2009 09:37
Last Modified: 09 Oct 2009 09:37
Published Version: http://dx.doi.org/10.1186/ar1650
Status: Published
URI: http://eprints.whiterose.ac.uk/id/eprint/9706

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