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Reduced models of striatal neurons: dopamine modulation and dynamics

Humphries, M., Lepora, N., Wood, R. and Gurney, K. (2009) Reduced models of striatal neurons: dopamine modulation and dynamics. In: Eighteenth Annual Computational Neuroscience Meeting, 18 - 23 July 2009, Berlin, Germany.

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Abstract

Loss of dopamine cells in Parkinson's Disease and its animal models leads to profound motor deficits. An intact dopamine system also seems to be critical for many forms of learning [1]. Much work on understanding these roles of dopamine has focused on the striatum, the main input nucleus of the basal ganglia, as the striatum is the main locus of dopamine's action in the verterbrate brain [2]. Damage to the striatum itself also impairs both motor action and learning [3]. Thus, the twin problems of understanding the computational roles of dopamine and the striatum are inseparably intertwined.

Item Type: Conference or Workshop Item (Poster)
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 09 Oct 2009 11:23
Last Modified: 09 Oct 2009 11:23
Published Version: http://www.biomedcentral.com/1471-2202/10/S1/P321
Status: Published
URI: http://eprints.whiterose.ac.uk/id/eprint/9670

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