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Cortico-striatal plasticity for action-outcome learning using spike timing dependent eligibility

Gurney, K., Humphries, M. and Redgrave, P. (2009) Cortico-striatal plasticity for action-outcome learning using spike timing dependent eligibility. In: Eighteenth Annual Computational Neuroscience Meeting: CNS 2009, 18–23 July 2009, Berlin, Germany.

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We recently proposed that short-latency, sensory-evoked dopamine release is critical for learning action-outcome causality [1]. If an action causes an unexpected outcome associated with a phasic visual event, there will be a phasic burst of dopamine in the striatum. Subsequent reinforcement of the striatal response to the cortical representation of the action then makes the selection of the action (and its outcome) more likely; i.e. there is "repetition biasing" of action selection. This, in turn, facilitates associative learning of the action-outcome pairing elsewhere in the brain. Here, we present a model of cortico-striatal plasticity in medium spiny neurons (MSNs) that could form the basis for a quantitative account of action-outcome learning in basal ganglia.

Item Type: Conference or Workshop Item (Poster)
Copyright, Publisher and Additional Information: © 2009 Gurney et al; licensee BioMed Central Ltd.
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield)
Depositing User: Sheffield Import
Date Deposited: 05 Oct 2009 10:45
Last Modified: 08 Oct 2009 09:45
Published Version: http://www.biomedcentral.com/1471-2202/10/S1/P135
Status: Published
URI: http://eprints.whiterose.ac.uk/id/eprint/9660

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