Azzarito, V, Rowell, P, Barnard, A et al. (4 more authors) (2016) Probing Protein Surfaces: QSAR Analysis using Helix Mimetics. ChemBioChem, 17 (8). pp. 768-773. ISSN 1439-4227
Abstract
α-Helix-mediated protein–protein interactions (PPIs) are important targets for small-molecule inhibition; however, generic approaches to inhibitor design are in their infancy and would benefit from QSAR analyses to rationalise the noncovalent basis of molecular recognition by designed ligands. Using a helix mimetic based on an oligoamide scaffold, we have exploited the power of a modular synthesis to access compounds that can readily be used to understand the noncovalent determinants of hDM2 recognition by this series of cell-active p53/hDM2 inhibitors.
Metadata
Authors/Creators: |
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Keywords: | chemical biology; foldamers; helix mimetics; p53/hDM2; protein–protein interactions | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 26 May 2016 15:17 | ||||
Last Modified: | 26 May 2016 15:17 | ||||
Published Version: | http://dx.doi.org/10.1002/cbic.201500504 | ||||
Status: | Published | ||||
Publisher: | Wiley-VCH Verlag | ||||
Identification Number: | https://doi.org/10.1002/cbic.201500504 | ||||
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