Royle, J, Dobson, SJ, Muller, M et al. (1 more author) (2015) Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? Viruses, 7 (10). 5375 - 5387. ISSN 1999-4915
Abstract
Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention.
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Copyright, Publisher and Additional Information: | © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | ||||||
Keywords: | DNA virus; viroporin; papillomavirus; polyomavirus | ||||||
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Institution: | The University of Leeds | ||||||
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) | ||||||
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Depositing User: | Symplectic Publications | ||||||
Date Deposited: | 03 Nov 2015 11:26 | ||||||
Last Modified: | 12 Feb 2019 13:47 | ||||||
Published Version: | http://dx.doi.org/10.3390/v7102880 | ||||||
Status: | Published | ||||||
Publisher: | MDPI | ||||||
Identification Number: | https://doi.org/10.3390/v7102880 |