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Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study

Scarle, S. and Clayton, R.H. (2009) Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study. Medical and Biological Engineering and Computing, 47 (3). pp. 291-300. ISSN 1741-0444


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Afterdepolarisations are associated with arrhythmias in the heart, but are difficult to study experimentally. In this study we used a simplified computational model of 1D and 2D cardiac ventricular tissue, where we could control the size of the region generating afterdepolarisations, as well as the properties of the afterdepolarisation waveform. Provided the size of the afterdepolarisation region was greater than around 1 mm, propagating extrasystoles were produced in both 1D and 2D. The number of extrasystoles produced depended on the amplitude, period, and duration of the oscillatory EAD waveform. In 2D, re-entry was also initiated for specific combinations of EAD amplitude, period, and duration, with the afterdepolarisation region acting as a common pathway. The main finding from this modelling study is therefore that afterdepolarisations can act as potent sources of propagating extrasystoles, as well as a source of re-entrant activation.

Item Type: Article
Copyright, Publisher and Additional Information: © 2009 Springer. This is an author produced version of a paper subsequently published in Medical and Biological Engineering and Computing. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: Heart; Re-entry; Fibrillation; Excitable media; Early afterdepolarisations
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield)
Depositing User: Miss Anthea Tucker
Date Deposited: 23 Jul 2009 10:13
Last Modified: 15 Sep 2014 01:36
Published Version: http://dx.doi.org/10.1007/s11517-008-0405-0
Status: Published
Publisher: Springer
Identification Number: 10.1007/s11517-008-0405-0
URI: http://eprints.whiterose.ac.uk/id/eprint/8739

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