Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism

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Pettit, L.J., Browne, H.P., Yu, L. et al. (10 more authors) (2014) Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism. BMC Genomics, 15. 160. 160 - 160. ISSN 0094-8276

Abstract

Metadata

Authors/Creators:
  • Pettit, L.J.
  • Browne, H.P.
  • Yu, L.
  • Smits, W.K.
  • Fagan, R.P.
  • Barquist, L.
  • Martin, M.J.
  • Goulding, D.
  • Duncan, S.H.
  • Flint, H.J.
  • Dougan, G.
  • Choudhary, J.S.
  • Lawley, T.D.
Copyright, Publisher and Additional Information: © 2014 Pettit et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Clostridium difficile; Spo0A; RNAseq; Proteomics; Sporulation; Virulence; Metabolism; Butyrate; Transmission; Genome annotation
Dates:
  • Published: February 2014
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 02 Mar 2015 10:22
Last Modified: 23 Mar 2018 22:10
Published Version: http://dx.doi.org/10.1186/1471-2164-15-160
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: https://doi.org/10.1186/1471-2164-15-160

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Filename: 1471-2164-15-160-s1.pdf

Description: Identification of differentially expressed genes in C. difficile 630∆erm spo0A mutant by transcriptional profiling.

Filename: 1471-2164-15-160-s2.xlsx

Description: Table summarizing genes differentially expressed in a C. difficile spo0A mutant relative to the parental strain based on transcriptomics and proteomics.

Filename: 1471-2164-15-160-s3.docx

Description: Table summarizing gene regulation genes that are controlled by C. difficile Spo0A.

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