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Emergence of spontaneous rhythm disorders in self-assembled networks of heart cells

Soen, Y., Cohen, N. and Braun, E. (1999) Emergence of spontaneous rhythm disorders in self-assembled networks of heart cells. Physical Review Letters, 82 (17). pp. 3556-3559. ISSN 1079-7114

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Abstract

A noninvasive optical recording technique is introduced to study the spontaneous contractile activity in self-assembled heart cell networks. Continuous monitoring throughout the lifetime of the network reveals spontaneous appearance of various rhythm disorders. Analysis of two typical patterns, namely, subharmonic structures and sudden alternations between two dominant rates, indicates the emergence of intrinsic pacemakers. A model of one or two slightly variable nonlinear oscillators, acting on an excitable element, is shown to reproduce the main experimental results.

Item Type: Article
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Engineering (Leeds) > School of Computing (Leeds)
Depositing User: Miss Jamie Grant
Date Deposited: 12 Mar 2009 18:49
Last Modified: 15 Sep 2014 01:39
Published Version: http://dx.doi.org/10.1103/PhysRevLett.82.3556
Status: Published
Publisher: American Physical Society
Identification Number: 10.1103/PhysRevLett.82.3556
URI: http://eprints.whiterose.ac.uk/id/eprint/7965

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