Lynch, S, Baker, H, Byker, SG et al. (2 more authors) (2009) Single Molecule Force Spectroscopy on G-Quadruplex DNA. Chemistry - A European Journal, 15 (33). 8113 - 8116. ISSN 0947-6539
Abstract
Mechanical unfolding of a guanine (G)-quadruplex! A bimolecular Gquadruplex was formed between a pair of single-stranded DNAs on an AFM probe and a flat gold surface (see figure). The resulting G-quadruplex was studied by single-molecule force spectroscopy as a function of K+ concentration and the force loading rate. The mechanical stability and kinetic and thermodynamic parameters of the G-quadruplexes were estimated.
Metadata
| Authors/Creators: |
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| Keywords: | atomic force microscopy; DNA; G-quadruplex; single-molecule studies |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 27 Jun 2013 11:48 |
| Last Modified: | 27 Jun 2013 11:48 |
| Published Version: | http://dx.doi.org/10.1002/chem.200901390 |
| Status: | Published |
| Publisher: | Wiley-VCH Verlag |
| Identification Number: | https://doi.org/10.1002/chem.200901390 |
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