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The capture of flowing microbubbles with an ultrasonic tap using acoustic radiation force.

Raiton, B, McLaughlan, JR, Harput, S, Smith, PR, Cowell, DMJ and Freear, S (2012) The capture of flowing microbubbles with an ultrasonic tap using acoustic radiation force. Applied Physics Letters, 101 (4). 044102 - 044102. ISSN 0003-6951

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The accumulation of 1–10 μm phospholipid-shelled microbubbles was demonstrated by creating an “ultrasonic tap” using acoustic travelling waves. Microbubbles were flowed through a 200 μm cellulose tube at rates ranging between 14–50 ml/h, in order to approximate the velocities and wall shear rates found throughout the human circulatory system. The generated acoustic radiation force directly opposing the flow direction was sufficient to hold microbubbles in a fluid flow up to 28 cm/s. Clusters of microbubbles subject to wall shear rates of up to 9000 s−1 were retained near a pressure null for several seconds.

Item Type: Article
Copyright, Publisher and Additional Information: © 2012, American Institute of Physics. This is an author produced version of a paper published in Applied Physics Letters. Uploaded in accordance with the publisher's self-archiving policy.
Keywords: microbubbles, ultrasound, sonothrombolysis, radiation force
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Engineering (Leeds) > School of Electronic & Electrical Engineering (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 20 Aug 2012 09:59
Last Modified: 07 Jun 2014 15:34
Published Version: http://dx.doi.org/10.1063/1.4739514
Status: Published
Publisher: Applied Physics Letter
Identification Number: 10.1063/1.4739514
URI: http://eprints.whiterose.ac.uk/id/eprint/74466

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