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Reorganization of human cortical maps caused by inherited photoreceptor abnormalities

Baseler, H.E., Brewer, A.A., Sharpe, L.T., Morland, A.B., Jägle, H. and Wandell, B.A. (2002) Reorganization of human cortical maps caused by inherited photoreceptor abnormalities. Nature Neuroscience, 5 (4). pp. 364-370. ISSN 1097-6256

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Published Version: http://dx.doi.org/10.1038/nn817

Abstract

We describe a compelling demonstration of large-scale developmental reorganization in the human visual pathways. The developmental reorganization was observed in rod monochromats, a rare group of congenitally colorblind individuals who virtually lack cone photoreceptor function. Normal controls had a cortical region, spanning several square centimeters, that responded to signals initiated in the all-cone foveola but was inactive under rod viewing conditions; in rod monochromats this cortical region responded powerfully to rod-initiated signals. The measurements trace a causal pathway that begins with a genetic anomaly that directly influences sensory cells and ultimately results in a substantial central reorganization.

Item Type: Article
Academic Units: The University of York > Psychology (York)
Depositing User: York RAE Import
Date Deposited: 12 Mar 2009 16:21
Last Modified: 12 Mar 2009 16:21
Published Version: http://dx.doi.org/10.1038/nn817
Status: Published
Publisher: Nature Publishing Group
Identification Number: 10.1038/nn817
URI: http://eprints.whiterose.ac.uk/id/eprint/7101

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