Baseler, H.E., Brewer, A.A., Sharpe, L.T. et al. (3 more authors) (2002) Reorganization of human cortical maps caused by inherited photoreceptor abnormalities. Nature Neuroscience, 5 (4). pp. 364-370. ISSN 1097-6256
We describe a compelling demonstration of large-scale developmental reorganization in the human visual pathways. The developmental reorganization was observed in rod monochromats, a rare group of congenitally colorblind individuals who virtually lack cone photoreceptor function. Normal controls had a cortical region, spanning several square centimeters, that responded to signals initiated in the all-cone foveola but was inactive under rod viewing conditions; in rod monochromats this cortical region responded powerfully to rod-initiated signals. The measurements trace a causal pathway that begins with a genetic anomaly that directly influences sensory cells and ultimately results in a substantial central reorganization.
|Institution:||The University of York|
|Academic Units:||The University of York > Psychology (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||12 Mar 2009 16:21|
|Last Modified:||12 Mar 2009 16:21|
|Publisher:||Nature Publishing Group|