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A tiling approach to virus capsid assembly explaining a structural puzzle in virology

Twarock, R. (2004) A tiling approach to virus capsid assembly explaining a structural puzzle in virology. Journal of Theoretical Biology, 226 ( 4). pp. 477-482. ISSN 0022-5193

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A novel approach for the description of the protein stoichiometry of viral capsids, that is the protein shells protecting the viral genome, is introduced based on tiling theory. This approach generalizes Caspar–Klug theory of quasi-equivalence to account also for non-quasi-equivalent subunit arrangements in icosahedral virus capsids that have been observed experimentally but are not covered by the Caspar–Klug approach. In particular, the new approach is used to explain the structure of polyoma virus, Simian Virus 40 and L-A virus capsids, which are considered structural puzzles in view of Caspar–Klug theory.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Mathematics (York)
Depositing User: York RAE Import
Date Deposited: 02 Apr 2009 13:20
Last Modified: 02 Apr 2009 13:20
Published Version: http://dx.doi.org/10.1016/j.jtbi.2003.10.006
Status: Published
Publisher: Elsevier Science B.V.
Refereed: Yes
Identification Number: 10.1016/j.jtbi.2003.10.006
URI: http://eprints.whiterose.ac.uk/id/eprint/6947

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