Twarock, R. and Hendrix, R.W. (2006) Crosslinking in viral capsids via tiling theory. Journal of Theoretical Biology, 240 (3). pp. 419-424. ISSN 0022-5193Full text not available from this repository.
A vital part of a virus is its protein shell, called the viral capsid, that encapsulates and hence protects the viral genome. It has been shown in Twarock [2004. A tiling approach to vius capsids assembly explaining a structural puzzle in virology. J. Theor. Biol. 226, 477-482] that the surface structures of viruses with icosahedrally symmetric capsids can be modelled in terms of tilings that encode the locations of the protein subunits. This theory is extended here to multi-level tilings in order to model crosslinking structures. The new framework is demonstrated for the case of bacteriophage HK97, and it is shown, how the theory can be used in general to decide if crosslinking, and what type of crosslinking, is compatible from a mathematical point of view with the geometrical surface structure of a virus.
|Institution:||The University of York|
|Academic Units:||The University of York > Biology (York)
The University of York > Mathematics (York)
|Depositing User:||York RAE Import|
|Date Deposited:||02 Apr 2009 13:40|
|Last Modified:||02 Apr 2009 13:40|
|Publisher:||Elsevier Science B.V.|