Whitehead, D.M., Jackson, T., McKeown, S.C., Wilson, K. and Routledge, A. (2002) Application of X-ray photoelectron Sspectroscopy in determining the structure of solid-phase bound substrates. Journal Of Combinatorial Chemistry, 4 (4). pp. 255-257. ISSN 1520-4766
The synthesis of compounds on solid supports has grown rapidly in the past 10 years, but one of the hurdles to the routine adoption of solid-supported chemistry is the limited number of analytical methods available to characterize resin-bound compounds. There have been methods developed for on-bead reaction monitoring of solid-phase reactions; both magic angle spinning (MAS) NMR1 and FTIR2 are useful techniques, but much solid-phase chemistry still relies on releasing the product from the solid support for validation. As a result, there still remains the need for complementary techniques that could quantify and/or identify functional groups prepared during solid-phase synthesis.
|Institution:||The University of York|
|Academic Units:||The University of York > Chemistry (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||23 Apr 2009 13:31|
|Last Modified:||23 Apr 2009 13:31|
|Publisher:||American Chemical Society|