Brealey, S., Atwell, C., Gilbert, F., Gillan, M., Bryan, S., Coulton, S., Cox, H., Cross, B., Fylan, F., Garratt, A., Gilbert, F. and Gillan, M. (2007) Using postal randomization to replace telephone randomization had no significant effect on recruitment of patients. Journal of Clinical Epidemiology, 60 (10). pp. 1046-1051. ISSN 0895-4356
To test the effect of postal randomization on recruitment of patients into a randomized trial in primary care.
Study Design and Setting
General practices used a telephone service to randomize patients in our trial. Delays in the start of recruitment at some sites led us to modify the randomization procedure. When new practices took part patients completed and posted baseline materials to the Trial Secretary in York who performed the randomization and informed those concerned of the allocation.
Of the 647 practices who were invited to take part, 130 (45%) of 288 agreed to participate using telephone randomization and 155 (43%) of 359 using the postal method. These practices recruited 553 patients from November 2002 to October 2004 across 11 sites in the United Kingdom. The postal method reduced the number of patients recruited by a factor of 0.86 (95% confidence interval = 0.62–1.20), or 14%. The number of general practitioners working in a practice significantly increased patient recruitment by a factor of 1.12 (1.05–1.20), whereas practice distance from hospital significantly decreased recruitment by a factor of 0.98 (0.97–0.99).
Postal randomization had no significant effect on recruitment of patients into our trial.
|Keywords:||Patient recruitment; Family practice; Randomized controlled trial; Magnetic resonance imaging; Internal derangement of the knee; Negative binomial regression|
|Institution:||The University of York|
|Academic Units:||The University of York > Health Sciences (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||29 May 2009 10:40|
|Last Modified:||29 May 2009 10:40|