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Allergy and risk of childhood leukaemia: Results from the UKCCS

Hughes, A.M., Lightfoot, T., Simpson, J., Ansell, P., McKinney, P.A., Kinsey, S.E., Mitchell, C.D., Eden, T.O.D., Greaves, M. and Roman, E. (2007) Allergy and risk of childhood leukaemia: Results from the UKCCS. International Journal of Cancer, 121 (4). pp. 819-824. ISSN 0020-7136

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Abstract

We investigated the relationship between childhood leukaemia and preceding history of allergy. A nationwide case-control study of childhood cancers was conducted in the United Kingdom with population-based sampling of cases (n = 839) and controls (n = 1,337), matched on age, sex and region of residence. Information about clinically diagnosed allergies was obtained from primary care records. More than a third of subjects had at least one allergy diagnosed prior to leukaemia diagnosis (cases) or pseudo-diagnosis (controls). For both total acute lymphoblastic leukaemia (ALL) and common-ALL/precursor B-cell ALL (c-ALL), a history of eczema was associated with a 30% significant reduction in risk: the odds ratios (OR) and 95% confidence intervals (CI) were 0.70 (0.51-0.97) and 0.68 (0.48-0.98), respectively. Similar associations were observed for hayfever (OR = 0.47; 95% CI: 0.26-0.85 and OR = 0.62; 95% CI: 0.33-1.16 for ALL and c-ALL, respectively). No such patterns were seen either for asthma and ALL, or for any allergy and acute myeloid leukaemia. A comparative analysis of primary care records with parents recall of allergy revealed only moderate agreement with contemporaneous clinical diagnoses for both cases and controls - confirming the unreliability of parental report at interview. Our finding of a reciprocal relationship between allergy and ALL in children is compatible with the hypothesis that a dysregulated immune response is a critical determinant of childhood ALL.

Item Type: Article
Institution: The University of York
Academic Units: The University of York > Health Sciences (York)
Depositing User: York RAE Import
Date Deposited: 28 May 2009 13:19
Last Modified: 28 May 2009 13:19
Published Version: http://dx.doi.org/10.1002/ijc.22702
Status: Published
Publisher: John Wiley & Sons
Identification Number: 10.1002/ijc.22702
URI: http://eprints.whiterose.ac.uk/id/eprint/6293

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