Oliver, S.E., Barrass, B., Gunnell, D.J., Donovan, J.L., Peters, T.J., Persad, R.A., Gillatt, D., Neal, D.E., Hamdy, F.C. and Holly, J.M. P. (2004) Serum Insulin-Like Growth Factor-I Is Positively Associated With Serum Prostate-Specific Antigen in Middle-Aged Men Without Evidence of Prostate Cancer. Cancer Epidemiology Biomarkers & Prevention, 13 (1). pp. 163-165. ISSN 1055-9965
We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.
|Institution:||The University of York|
|Academic Units:||The University of York > Hull York Medical School (York)|
|Depositing User:||York RAE Import|
|Date Deposited:||10 Aug 2009 10:04|
|Last Modified:||10 Aug 2009 10:04|
|Publisher:||American Association for Cancer Research|