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Serum Insulin-Like Growth Factor-I Is Positively Associated With Serum Prostate-Specific Antigen in Middle-Aged Men Without Evidence of Prostate Cancer

Oliver, S.E., Barrass, B., Gunnell, D.J., Donovan, J.L., Peters, T.J., Persad, R.A., Gillatt, D., Neal, D.E., Hamdy, F.C. and Holly, J.M. P. (2004) Serum Insulin-Like Growth Factor-I Is Positively Associated With Serum Prostate-Specific Antigen in Middle-Aged Men Without Evidence of Prostate Cancer. Cancer Epidemiology Biomarkers & Prevention, 13 (1). pp. 163-165. ISSN 1055-9965

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Abstract

We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

Item Type: Article
Academic Units: The University of York > Hull York Medical School (York)
Depositing User: York RAE Import
Date Deposited: 10 Aug 2009 10:04
Last Modified: 10 Aug 2009 10:04
Published Version: http://dx.doi.org/10.1158/1055-9965.EPI-03-0102
Status: Published
Publisher: American Association for Cancer Research
Identification Number: 10.1158/1055-9965.EPI-03-0102
URI: http://eprints.whiterose.ac.uk/id/eprint/5835

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