White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

A phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin's lymphoma

Burton, C., Linch, D., Hoskin, P., Milligan, D., Dyer, M.J.S., Hancock, B., Mouncey, P., Smith, P., Qian, W., MacLennan, K., Jack, A., Webb, A. and Cunningham, D. (2006) A phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin's lymphoma. British Journal of Cancer, 94 (6). pp. 806-813. ISSN 0007-0920

Full text not available from this repository.

Abstract

The management of older patients with aggressive non-Hodgkin's lymphoma presents a challenge to the physician. Age is a poor prognostic indicator, due to reduced ability to tolerate and maintain dose-intensive chemotherapy. Generally, older patients demonstrate a lower response rate, reduced survival and increased toxicity, although the majority of large randomised trials exclude older patients. This randomised trial was conducted in patients 60 years or over to compare CHOP (cyclophosphamide 750 mg m-2, doxorubicin 50 mg m-2, vincristine 1.4 mg m-2, prednisolone 100 mg) with PMitCEBO (mitoxantrone 7 mg m-2, cyclophosphamide 300 mg m-2, etoposide 150 mg m-2, vincristine 1.4 mg m-2, bleomycin 10 mg m-2 and prednisolone 50 mg). Due to the myelosuppressive nature of these regimens, patients were also randomised to the addition of G-CSF. The formal results of this trial with long-term follow-up are now reported. Data were analysed to assess efficacy and toxicity. Overall response rate was 84% in the CHOP arm and 83% in the PMitCEBO arm, with overall response rates of 83% for the use of G-CSF and 84% for no G-CSF. At median 44 months follow-up, there was no significant difference in failure-free, progression-free or overall survival between the CHOP and PMitCEBO arms. At 3 years, the actuarial failure-free survival was 44% in CHOP recipients and 42% in PMitCEBO recipients and the 3-year actuarial overall survival was 46% and 45% respectively. There was no significant difference in the failure-free, progression-free or overall survival with the addition of G-CSF.

Item Type: Article
Keywords: elderly, non-Hodgkin's lymphoma, CHOP, PMitCEBO, G-CSF
Institution: The University of York
Academic Units: The University of York > Health Sciences (York)
Depositing User: York RAE Import
Date Deposited: 12 Aug 2009 13:33
Last Modified: 12 Aug 2009 13:33
Published Version: http://dx.doi.org/10.1038/sj.bjc.6602975
Status: Published
Publisher: Nature Publishing Group
Identification Number: 10.1038/sj.bjc.6602975
URI: http://eprints.whiterose.ac.uk/id/eprint/5739

Actions (repository staff only: login required)