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Expression of alpha-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study.

Goode, NP, Shires, M, Khan, TN and Mooney, AF (2004) Expression of alpha-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study. Nephrology Dialysis Transplantation, 19 (4). 844 - 851 . ISSN 0931-0509

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Abstract

The molecular basis for the alteration of glomerular podocyte phenotype in nephrotic syndrome probably involves adaptive changes of the actin cytoskeleton. alpha-Actinin-4 is an actin cross-linking protein that also interacts with intra- and intercellular adhesion molecules and elements of the transmembrane signal transduction pathway and is implicated in nephrotic syndrome by animal models and human genetic studies.

Item Type: Article
Keywords: Actinin, Adolescent, Adult, Aged, Child, Female, Gold, Humans, Male, Microfilament Proteins, Microscopy, Immunoelectron, Middle Aged, Nephrotic Syndrome
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 16 Apr 2012 11:18
Last Modified: 08 Feb 2013 17:37
Published Version: http://dx.doi.org/10.1093/ndt/gfg620
Status: Published
Publisher: Oxford University Press
Identification Number: 10.1093/ndt/gfg620
URI: http://eprints.whiterose.ac.uk/id/eprint/43853

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