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Virulence factors in pneumococcal respiratory pathogenesis

Preston, J. A. and Dockrell, D. H. (2008) Virulence factors in pneumococcal respiratory pathogenesis. Future microbiology, 3 (2). pp. 205-21. ISSN 1746-0921

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Streptococcus pneumoniae (the pneumococcus) is a major global cause of human disease. Since the publication of the entire sequence of TIGR4 in 2001, our understanding of this human pathogen has increased significantly. Genetic studies, and the use of mutant strains have refined our understanding of the pathogenic mechanisms of classic pneumococcal virulence factors, including the polysaccharide capsule, pneumolysin and surface-expressed proteins. Genetic screens are identifying novel virulence factors. Characterization of pili and bacteriocins, as well as genes associated with competence, metabolism and resistance to oxidative stress has provided new insights into the genetic diversity of the pneumococcus. Further appreciation of the molecular basis of pneumococcal pathogenesis will lead to more effective strategies for the prevention and management of pneumococcal disease.

Item Type: Article
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Infection & Immunity
Depositing User: Miss Anthea Tucker
Date Deposited: 29 Mar 2012 09:54
Last Modified: 29 Mar 2012 09:54
Published Version: http://dx.doi.org/10.2217/17460913.3.2.205
Status: Published
Publisher: Future Medicine
Identification Number: 10.2217/17460913.3.2.205
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/43798

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