Mulhern, B. and Meadows, K. (2011) Estimating the minimally important difference (MID) of the Diabetes Health Profile-18 (DHP-18) for Type 1 and Type 2 Diabetes Mellitus. Discussion Paper. (Unpublished)
Aims: The DHP-18 is a widely used measure of health related quality of life in diabetes mellitus but it is unclear what constitutes a meaningful change in score on each domain. The aim of this study was to establish estimates for the minimally important difference (MID) for each of the domains.
Methods: The MID for each domain was estimated using both anchor and distribution based approaches which were applied to data from both the United Kingdom and France. A range of anchors were tested.
Results: A global health change anchor was found to be more acceptable for Type 1 diabetes than for Type 2. MID estimates varied by domain, by estimation approach used, and by diabetes type. For Type 1 diabetes the Psychological Distress domain estimates ranged from 2.86 to 11.05, Barriers to Activity domain from 2.87 to 11.32 and Disinhibited Eating domain from 1.03 to 11.53. For Type 2 diabetes the Psychological Distress estimates ranged from 0.94 to 9.71; Barriers to Activity from 1.66 to 9.88 and Disinhibited Eating from 0.90 to 11.64.
Conclusions: This is the first attempt to derive estimates for the MID of an English language measure of health related quality of life in diabetes. For Type 1 diabetes we recommend using the mean MID value using both approaches. For Type 2 we recommend applying more weight to the distribution based estimations. The MID values identified in this study will help clinicians and researchers using the DHP-18 to identify clinically meaningful change in patient reported outcomes.
|Item Type:||Monograph (Discussion Paper)|
|Keywords:||Minimally Important Difference, DHP-18, diabetes mellitus|
|Institution:||The University of Sheffield|
|Academic Units:||The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science > HEDS Discussion Paper Series|
|Depositing User:||ScHARR / HEDS (Sheffield)|
|Date Deposited:||27 Jul 2011 17:12|
|Last Modified:||16 Jun 2014 20:30|
|Identification Number:||HEDS Discussion Paper 11/08|