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Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina

Bourke, L., Tew, G.A., Milo, M., Crossman, D.C., Saxton, J.M. and Chico, T.J.A. (2010) Study protocol: a randomised controlled trial investigating the effect of exercise training on peripheral blood gene expression in patients with stable angina. BMC Public Health, 10. Art no.620. ISSN 1471-2458

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Abstract

Background: Exercise training has been shown to reduce angina and promote collateral vessel development in patients with coronary artery disease. However, the mechanism whereby exercise exerts these beneficial effects is unclear. There has been increasing interest in the use of whole genome peripheral blood gene expression in a wide range of conditions to attempt to identify both novel mechanisms of disease and transcriptional biomarkers. This protocol describes a study in which we will assess the effect of a structured exercise programme on peripheral blood gene expression in patients with stable angina, and correlate this with changes in angina level, anxiety, depression, and exercise capacity.

Methods/Design: Sixty patients with stable angina will be recruited and randomised 1: 1 to exercise training or conventional care. Patients randomised to exercise training will attend an exercise physiology laboratory up to three times weekly for supervised aerobic interval training sessions of one hour in total duration. Patients will undergo assessments of angina, anxiety, depression, and peripheral blood gene expression at baseline, after six and twelve weeks of training, and twelve weeks after formal exercise training ceases.

Discussion: This study will provide comprehensive data on the effect of exercise training on peripheral blood gene expression in patients with angina. By correlating this with improvement in angina status we will identify candidate peripheral blood transcriptional markers predictive of improvements in angina level in response to exercise training.

Item Type: Article
Copyright, Publisher and Additional Information: © 2010 Bourke et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Coronary-Artery-Disease; Collateral Flow; Heart-Disease; Rehabilitation; Depression; Inventory
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Department of Cardiovascular Science
Depositing User: Miss Anthea Tucker
Date Deposited: 08 Dec 2010 10:38
Last Modified: 08 Feb 2013 17:29
Published Version: http://dx.doi.org/10.1186/1471-2458-10-620
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: 10.1186/1471-2458-10-620
URI: http://eprints.whiterose.ac.uk/id/eprint/42706

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