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Development and validation of computational models of cellular interaction

Smallwood, R.H. [r.smallwood@shef.ac.uk], Holcombe, W.M.L. and Walker, D.C. (2004) Development and validation of computational models of cellular interaction. Journal of Molecular Histology, 35 (7). pp. 659-665. ISSN 1567-2379


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In this paper we take the view that computational models of biological systems should satisfy two conditions – they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.

Item Type: Article
Copyright, Publisher and Additional Information: © 2004 Kluwer Academic Publishers. Further information at http://www.dcs.shef.ac.uk/~rod/Integrative_Systems_Biology.html
Keywords: Computational biology, modelling, individual-based modelling, validation, prediction
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield)
Depositing User: Rod Smallwood
Date Deposited: 28 Apr 2005
Last Modified: 06 Jun 2014 00:39
Published Version: http://www.springeronline.com/sgw/cda/frontpage/0,...
Status: Published
Refereed: Yes
Identification Number: 10.1007/s10735-004-2660-1
URI: http://eprints.whiterose.ac.uk/id/eprint/420

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