Development and validation of computational models of cellular interaction

Smallwood, R.H. [r.smallwood@shef.ac.uk], Holcombe, W.M.L. and Walker, D.C. (2004) Development and validation of computational models of cellular interaction. Journal of Molecular Histology, 35 (7). pp. 659-665. ISSN 1567-2379

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Abstract

In this paper we take the view that computational models of biological systems should satisfy two conditions – they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.

Item Type:	Article
Copyright, Publisher and Additional Information:	© 2004 Kluwer Academic Publishers. Further information at http://www.dcs.shef.ac.uk/~rod/Integrative_Systems_Biology.html
Keywords:	Computational biology, modelling, individual-based modelling, validation, prediction
Academic Units:	The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield)
Depositing User:	Rod Smallwood
Date Deposited:	28 Apr 2005
Last Modified:	08 Feb 2013 16:47
Published Version:	http://www.springeronline.com/sgw/cda/frontpage/0,...
Status:	Published
Refereed:	Yes
Identification Number:	10.1007/s10735-004-2660-1
URI:	http://eprints.whiterose.ac.uk/id/eprint/420

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