White Rose University Consortium logo
University of Leeds logo University of Sheffield logo York University logo

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway

Koudijs, M.J., den Broeder, M.J., Groot, E. and van Eeden, F.J.M. (2008) Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Developmental Biology, 8 (15). ISSN 1471-213X

Full text not available from this repository.

Abstract

Aberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, differentiation and patterning, but mainly as a result of a loss of its activity. We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway

Item Type: Article
Copyright, Publisher and Additional Information: © 2008 Koudijs et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biological Sciences (Sheffield) > Department of Biomedical Science (Sheffield)
Depositing User: Sherpa Assistant
Date Deposited: 09 May 2008 15:41
Last Modified: 09 May 2008 15:41
Published Version: http://dx.doi.org/10.1186/1471-213X-8-15
Status: Published
Publisher: Biomed Central Ltd
Refereed: Yes
Identification Number: 10.1186/1471-213X-8-15
URI: http://eprints.whiterose.ac.uk/id/eprint/3781

Actions (login required)

View Item View Item