Healy, P.J., Groves, C., Chandramohan, M. and Helliwell, P.S. (2008) MRI changes in psoriatic dactylitisextent of pathology, relationship to tenderness and correlation with clinical indices. Rheumatology, 47 (1). pp. 92-95. ISSN 1462-0324Full text available as:
Available under licence : See the attached licence file.
Objectives. To quantify the extent of inflammation in psoriatic dactylitis and to examine the relationship between clinical and magnetic resonance imaging (MRI) data in both tender and non-tender dactylitis.
Methods. Seventeen patients with psoriatic dactylitis underwent clinical assessment for 6 months after change of treatment, usually to methotrexate. Measures of dactylitis included the Leeds Dactylitis Index, the assessment tool used in the Infliximab in Psoriatic Arthritis Clinical Trial (IMPACT), a simple count of tender dactlylitic digits and a count of all dactylitic digits, both tender and non-tender. MRI scans of the affected hand or foot were performed before and after treatment using a 1.5T Siemens scanner pre- and post-contrast.
Results. All patients improved clinically, as did their respective dactylitis scores and MRI images. The findings on MRI in both dactylitic and non-dactylitic digits were profound and widespread. The difference between tender and non-tender dactylitis was quantitative rather than qualitative. Synovitis and soft-tissue oedema were the most frequent abnormalities being present in 69 of tender dactylitic digits but bone oedema and flexor tenosynovitis were also frequently seen. Soft-tissue oedema was circumferential and enhancing and not limited to association with the flexor or extensor tendons. None of the clinical indices of dactylitis showed a close relationship to the extent of MRI abnormalities.
Conclusions. MRI images demonstrate widespread abnormalities in digits of people with psoriatic arthritis. Tender dactylitic digits have more abnormalities than other digits but the relationship between clinical and MRI scores is not strong.
|Copyright, Publisher and Additional Information:||© 2008 Oxford University Press Ltd. This is an author produced version of a paper published in Rheumatology. Uploaded in accordance with the publisher's self archiving policy.|
|Keywords:||psoriatic arthritis, dactylitis, magnetic resonance imaging, measurement, outcome assessment, clinical trials|
|Institution:||The University of Leeds|
|Academic Units:||The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Musculoskeletal Disease (Leeds)|
|Depositing User:||Repository Administrator York|
|Date Deposited:||07 Feb 2008 15:07|
|Last Modified:||08 Feb 2013 17:05|
|Publisher:||Oxford University Press|