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Evidence for antibiotic induced Clostridium perfringens diarrhoea

Modi, N. and Wilcox, M.H. (2001) Evidence for antibiotic induced Clostridium perfringens diarrhoea. Journal of Clinical Pathology, 54 (10). pp. 748-751. ISSN 0021-9746

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Clostridium difficile is a well documented cause of antibiotic associated diarrhoea in hospitalised patients, but may account for only approximately 20% of all cases. This leader reviews the current knowledge and understanding of the pathogenesis, epidemiology, and diagnosis of non-food borne Clostridium perfringens diarrhoea. Although enterotoxigenic C perfringens has been implicated in some C difficile negative cases of antibiotic associated diarrhoea, C perfringens enterotoxin detection methods are not part of the routine laboratory investigation of such cases. Testing for C perfringens enterotoxin in faecal samples from patients with antibiotic associated diarrhoea and sporadic diarrhoea on a routine basis would have considerable resource implications. Therefore, criteria for initiating investigations and optimum laboratory tests need to be established. In addition, establishing the true burden of C perfringens antibiotic associated diarrhoea is important before optimum control and treatment measures can be defined.

Item Type: Article
Copyright, Publisher and Additional Information: © 2001 Journal of Clinical Pathology
Keywords: Clostridium perfringens, Clostridium difficile, hospital acquired infective diarrhoea
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds)
Depositing User: Sherpa Assistant
Date Deposited: 13 Mar 2006
Last Modified: 21 Aug 2015 02:29
Published Version: http://jcp.bmjjournals.com/cgi/content/full/54/10/...
Status: Published
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/256

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