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A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma

Kelly, S., Harris, K.M., Berry, E., Hutton, J., Roderick, P., Cullingworth, J., Gathercole, L. and Smith, M.A. (2001) A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma. Gut, 49 (4). pp. 534-539. ISSN 0017-5749

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Abstract

BACKGROUND: Endoscopic ultrasound (EUS) may be used for preoperative staging of gastro-oesophageal carcinoma but performance values given in the literature differ.

AIMS: To identify and synthesise findings from all articles on the performance of EUS in tumour, node, metastasis (TNM) staging of gastro-oesophageal carcinoma. Source—Published and unpublished English language literature, 1981–1996.

METHODS: Data on the staging performance of EUS were retrieved and evaluated. Summary receiver operator characteristic methodology was used for synthesis, and a summary estimate of performance, Q*, obtained. Multiple regression analysis was used to assess study validity and investigate reasons for differences in performance.

RESULTS: Twenty seven primary articles were assessed in detail. Thirteen supplied results for staging oesophageal cancer, 13 for gastric cancer, and four for cancers at the gastro-oesophageal junction. For gastric T staging, Q*=0.93 (95% confidence interval (CI) 0.91–0.95) and for oesophageal T staging, Q*=0.89 (95% CI 0.88– 0.92). For gastro-oesophageal T staging, including cancers at the gastrooesophageal junction, Q*=0.91 (95% CI 0.89–0.93). Inclusion of cases with nontraversable stenosis was found to slightly reduce staging performance. For N staging, Q*=0.79 (95% CI 0.75–0.83). In articles that compared EUS directly with incremental computed tomography, EUS performed better. None of the variables assessed in the regression analysis was significant using a Bonferroni correction. Three variables (anatomical location, traversability, and blinding) showed strong relationships for future research and validation.

CONCLUSIONS: EUS is highly effective for discrimination of stages T1 and T2 from stages T3 and T4 for primary gastrooesophageal carcinomas. The failure rate of EUS from non-traversability of a stenotic cancer may be a limitation in some patient groups.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2001 by Gut
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Medical Physics (Leeds)
The University of Leeds > University of Leeds Research Centres and Institutes > Centre for Medical Imaging Research (Leeds)
Depositing User: Elizabeth Berry
Date Deposited: 13 Mar 2006
Last Modified: 07 Jun 2014 04:39
Published Version: http://www.gutjnl.com/
Status: Published
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/231

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