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Comparison of human uterine cervical electrical impedance measurements derived using two tetrapolar probes of different sizes

Gandhi, S.V., Walker, D.C., Brown, B.H. and Anumba, D.O.C. (2006) Comparison of human uterine cervical electrical impedance measurements derived using two tetrapolar probes of different sizes. BioMedical Engineering OnLine, 5 (62). ISSN 1475-925X

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Abstract

BACKGROUND

We sought to compare uterine cervical electrical impedance spectroscopy measurements employing two probes of different sizes, and to employ a finite element model to predict and compare the fraction of electrical current derived from subepithelial stromal tissue.

METHODS

Cervical impedance was measured in 12 subjects during early pregnancy using 2 different sizes of the probes on each subject.

RESULTS

Mean cervical resistivity was significantly higher (5.4 vs. 2.8 Ωm; p < 0.001) with the smaller probe in the frequency rage of 4–819 kHz. There was no difference in the short-term intra-observer variability between the two probes. The cervical impedance measurements derived in vivo followed the pattern predicted by the finite element model.

CONCLUSION

Inter-electrode distance on the probes for measuring cervical impedance influences the tissue resistivity values obtained. Determining the appropriate probe size is necessary when conducting clinical studies of resistivity of the cervix and other human tissues.

Item Type: Article
Copyright, Publisher and Additional Information: © 2006 Gandhi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Clinical Sciences Division South (Sheffield) > Department of Medical Physics and Clinical Engineering (Sheffield)
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine (Sheffield) > Clinical Sciences Division South (Sheffield) > Reproductive and Developmental Medicine (Sheffield)
The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield)
Depositing User: Sherpa Assistant
Date Deposited: 22 Jan 2007
Last Modified: 05 Jun 2014 19:08
Published Version: http://www.biomedical-engineering-online.com/conte...
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: 10.1186/1475-925X-5-62
URI: http://eprints.whiterose.ac.uk/id/eprint/1913

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