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CESAR: conventional ventilatory support vs extracorporeal membrane oxygenation for severe adult respiratory failure

Peek, G.J., Clemens, F., Elbourne, D., Firmin, R., Hardy, P., Hibbert, C., Killer, H., Mugford, M., Thalanany, M., Tiruvoipati, R., Truesdale, A. and Wilson, A. (2006) CESAR: conventional ventilatory support vs extracorporeal membrane oxygenation for severe adult respiratory failure. BMC Health Services Research, 6 (161). ISSN 1472-6963


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An estimated 350 adults develop severe, but potentially reversible respiratory failure in the UK annually. Current management uses intermittent positive pressure ventilation, but barotrauma, volutrauma and oxygen toxicity can prevent lung recovery. An alternative treatment, extracorporeal membrane oxygenation, uses cardio-pulmonary bypass technology to temporarily provide gas exchange, allowing ventilator settings to be reduced. While extracorporeal membrane oxygenation is proven to result in improved outcome when compared to conventional ventilation in neonates with severe respiratory failure, there is currently no good evidence from randomised controlled trials to compare these managements for important clinical outcomes in adults, although evidence from case series is promising.

Item Type: Article
Copyright, Publisher and Additional Information: © 2006 Peek et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield)
Depositing User: Sherpa Assistant
Date Deposited: 22 Jan 2007
Last Modified: 06 Jun 2014 05:49
Published Version: http://www.biomedcentral.com/1472-6963/6/163
Status: Published
Publisher: BioMed Central
Refereed: Yes
Identification Number: 10.1186/1472-6963-6-163
URI: http://eprints.whiterose.ac.uk/id/eprint/1908

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