O'Cathail, SM, Smith, T, Owens, R et al. (6 more authors) (2020) Superior outcomes of nodal metastases compared to visceral sites in oligometastatic colorectal cancer treated with stereotactic ablative radiotherapy. Radiotherapy and Oncology, 151. pp. 280-286. ISSN 0167-8140
Abstract
Background:
Stereotactic ablative radiotherapy (SBRT) is a radical option for oligometastatic colorectal cancer (CRC) patients, but most data relate to visceral metastases.
Methods:
A prospective, multi-centre database of CRC patients treated with SBRT was interrogated. Inclusion criteria were ECOG PS 0–2, ≤3 sites of disease, a disease free interval of >6 months unless synchronous liver metastases. Primary endpoints were local control (LC), progression free survival (PFS) and overall survival (OS).
Results:
163 patients (172 metastases) were analysed. The median FU was 16 months (IQR 12.2–22.85). The LC at 1 year was 83.8% (CI 76.4%−91.9%) with a PFS of 55% (CI 47%−64.7%) respectively. LC at 1 year was 90% (CI 83%−99%) for nodal metastases (NM), 75% (63%−90%) for visceral metastases (VM). NM had improved median PFS (9 vs 19 months) [HR 0.6, CI 0.38–0.94, p = 0.032] and median OS (32 months vs not reached) [HR 0.28, CI 0.18–0.7, p = 0.0062] than VM, regardless of whether the NM were located inside or outside the pelvis. On multivariate analysis, NM and ECOG PS 0 were significant good prognostic factors. An exploratory analysis suggests KRAS WT is also a good prognostic factor.
Conclusion:
Nodal site is an important prognostic determinant of SBRT that should incorporated into patient selection. We hypothesise this may have an immunoediting basis.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the terms of the Creative Commons Attribution 4.0 International (C (C BY 4.0) (https://creativecommons.org/licenses/by/4.0/) | ||||
Keywords: | Colorectal; Stereotactic; SBRT; Oligometastatic; Lymph node | ||||
Dates: |
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Institution: | The University of Leeds | ||||
Funding Information: |
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 23 Oct 2020 13:53 | ||||
Last Modified: | 23 Oct 2020 13:53 | ||||
Status: | Published | ||||
Publisher: | Elsevier | ||||
Identification Number: | https://doi.org/10.1016/j.radonc.2020.08.012 |