Valverde, P, Vendeville, J-B, Hollingsworth, K et al. (14 more authors) (2020) Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates. Chemical Communications. ISSN 1359-7345
Abstract
The first synthesis of 3-deoxy-3-fluoro-l-fucose is presented, which employs a d- to l-sugar translation strategy, and involves an enzymatic oxidation of 3-deoxy-3-fluoro-l-fucitol. Enzymatic activation (FKP) and glycosylation using an ą-1,2 and an ą-1,3 fucosyltransferase to obtain two fluorinated trisaccharides demonstrates its potential as a novel versatile chemical probe in glycobiology.
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Copyright, Publisher and Additional Information: | This article is protected by copyright. All rights reserved. This is an author produced version of an article published in Chemical Communications. Uploaded in accordance with the publisher's self-archiving policy. | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) | ||||
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 30 Apr 2020 16:07 | ||||
Last Modified: | 29 Apr 2021 00:38 | ||||
Status: | Published online | ||||
Publisher: | Royal Society of Chemistry | ||||
Identification Number: | https://doi.org/10.1039/D0CC02209H |