Refining rodent models of spinal cord injury

Abstract

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

Metadata

Authors/Creators:	Lilley, E Andrews, MR Bradbury, EJ Elliott, H Hawkins, P Ichiyama, RM https://orcid.org/0000-0002-7640-8032 Keeley, J Michael-Titus, AT Moon, LDF Pluchino, S Riddell, J Ryder, K Yip, PK
Copyright, Publisher and Additional Information:	© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/)
Keywords:	Animal model; Animal welfare; Refinement; Three Rs; Spinal cord injury; Spinal contusion; Spinal transection; Paralysis; Translational research; Regeneration; Tissue repair
Dates:	Accepted: 2 March 2020 Published (online): 3 March 2020 Published: June 2020
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	02 Apr 2020 13:44
Last Modified:	02 Apr 2020 13:44
Status:	Published
Publisher:	Elsevier
Identification Number:	https://doi.org/10.1016/j.expneurol.2020.113273

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Refining rodent models of spinal cord injury

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