Single cell deformation in shear and inertia dominant flow regimes

Armistead, FJ orcid.org/0000-0003-1274-5379, De Pablo, JG, Gadêlha, H et al. (2 more authors) (2017) Single cell deformation in shear and inertia dominant flow regimes. In: Proceedings of the 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2017: 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, 22-26 Oct 2017, Savannah, Georgia, USA. Chemical and Biological Microsystems Society , pp. 838-839. ISBN 978-0-692-94183-6

Abstract

We report new insight into cell deformability in inertia-dominant and shear-dominant flows. As a first model, we show that the deformability of HL60 cells changes with flow regime, which shows that flow regime can be used to probe different aspects of a cell’s internal structure. Additionally, we show the importance of flow regime when using deformability to distinguish between primary (SW480) and secondary (SW620) colorectal cancer cell lines.