Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition

Nicholson, L., Evans, C.A. orcid.org/0000-0003-4356-9216, Matheson, E. et al. (13 more authors) (2015) Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition. British Journal of Haematology, 171 (4). pp. 595-605. ISSN 0007-1048

Abstract

Metadata

Authors/Creators:
  • Nicholson, L.
  • Evans, C.A. https://orcid.org/0000-0003-4356-9216
  • Matheson, E.
  • Minto, L.
  • Keilty, C.
  • Sanichar, M.
  • Case, M.
  • Schwab, C.
  • Williamson, D.
  • Rainer, J.
  • Harrison, C.J.
  • Kofler, R.
  • Hall, A.G.
  • Redfern, C.P.F.
  • Whetton, A.D.
  • Irving, J.A.E.
Copyright, Publisher and Additional Information: © 2015 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, http://creativecommons.org/licenses/by/4.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: B cell differentiation; JNK signalling; childhood acute lymphoblastic leukaemia; glucocorticoid resistance; iTRAQ proteomics; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cell Differentiation; Cell Line, Tumor; Dexamethasone; Drug Resistance, Neoplasm; Exons; Gene Expression Regulation, Leukemic; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Multiplex Polymerase Chain Reaction; Mutation; Neoplasm Proteins; PAX5 Transcription Factor; Phosphorylation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proteomics; Real-Time Polymerase Chain Reaction; Tandem Mass Spectrometry
Dates:
  • Accepted: 1 July 2015
  • Published (online): 27 August 2015
  • Published: 1 November 2015
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 24 Jun 2019 14:09
Last Modified: 24 Jun 2019 14:09
Status: Published
Publisher: Wiley
Refereed: Yes
Identification Number: https://doi.org/10.1111/bjh.13647
Related URLs:

Share / Export

Statistics