Fc effector function contributes to the activity of human anti-CTLA-4 antibodies.

Arce Vargas, F., Furness, A.J.S., Litchfield, K. et al. (249 more authors) (2018) Fc effector function contributes to the activity of human anti-CTLA-4 antibodies. Cancer Cell, 33 (4). 649-663.e4. ISSN 1535-6108

Abstract

Metadata

Authors/Creators:
  • Arce Vargas, F.
  • Furness, A.J.S.
  • Litchfield, K.
  • Joshi, K.
  • Rosenthal, R.
  • Ghorani, E.
  • Solomon, I.
  • Lesko, M.H.
  • Ruef, N.
  • Roddie, C.
  • Henry, J.Y.
  • Spain, L.
  • Ben Aissa, A.
  • Georgiou, A.
  • Wong, Y.N.S.
  • Smith, M.
  • Strauss, D.
  • Hayes, A.
  • Nicol, D.
  • O'Brien, T.
  • Mårtensson, L.
  • Ljungars, A.
  • Teige, I.
  • Frendéus, B.
  • TRACERx Melanoma, Consortia
  • Harrrington, K.
  • Melcher, A.
  • Wotherspoon, A.
  • Francis, M.
  • TRACERx Renal, Consortia
  • Challacombe, B.
  • Larkin, J.
  • Fernando, A.
  • Hazell, S.
  • Chandra, A.
  • Pickering , L.
  • Lynch, J.
  • Rudman, S.
  • Chowdhury, S.
  • Harrison-Phipps, K.
  • Varia, M.
  • Horsfield, C.
  • Polson, A.
  • Stamp, G.
  • O'Donnell, M.
  • Drake, W.
  • Hill, P.
  • Hrouda, D.
  • Mayer, E.
  • Olsburgh, J.
  • Kooiman, G.
  • O'Connor, K.
  • Stewart, G.
  • Aitchison, M.
  • Tran, M.
  • Fotiadis, N.
  • Verma, H.
  • Lopez, J.
  • TRACERx Lung, Consortia
  • Lester, J.
  • Morgan, F.
  • Kornaszewska, M.
  • Attanoos, R.
  • Adams, H.
  • Davies, H.
  • Fennell, D.
  • Shaw, J.
  • Le Quesne, J.
  • Rathinam, S.
  • Nakas, A.
  • Rathinam, S.
  • Monteiro, W.
  • Marshall, H.
  • Nelson, L.
  • Bennett, J.
  • Riley, J.
  • Primrose, L.
  • Martinson, L.
  • Rathinam, S.
  • Marshall, H.
  • Anan, G.
  • Khan, S.
  • Nicolson, M.
  • Kerr, K.
  • Palmer, S.
  • Remmen, H.
  • Miller, J.
  • Buchan, K.
  • Chetty, M.
  • Gomersall, L.
  • Lock, S.
  • Naidu, B.
  • Langman, G.
  • Trotter, S.
  • Bellamy, M.
  • Bancroft, H.
  • Kerr, A.
  • Kadiri, S.
  • Webb, J.
  • Middleton, G.
  • Djearaman, M.
  • Summers, Y.
  • Califano, R.
  • Taylor, P.
  • Shah, R.
  • Krysiak, P.
  • Rammohan, K.
  • Fontaine, E.
  • Booton, R.
  • Evison, M.
  • Crosbie, P.
  • Moss, S.
  • Idries, F.
  • Novasio, J.
  • Joseph, L.
  • Bishop, P.
  • Chaturvedi, A.
  • Quinn, A.M.
  • Doran, H.
  • Leek, A.
  • Harrison, P.
  • Moore, K.
  • Waddington, R.
  • Blackhall, F.
  • Rogan, J.
  • Smith, E.
  • Dive, C.
  • Brady, G.
  • Rothwell, D.
  • Gulati, S.
  • Chemie, F.
  • Tugwood, J.
  • Pierce, J.
  • Lawrence, D.
  • Hayward, M.
  • Panagiotopoulos, N.
  • George, R.
  • Patrini, D.
  • Falzon, M.
  • Borg, E.
  • Khiroya, R.
  • Jamal-Hanjani, , M.
  • Wilson, G.
  • Birkbak, N.J.
  • Watkins, T.
  • McGranahan, N.
  • Abbosh, C.
  • Horswell, S.
  • Mitter, R.
  • Escudero, M.
  • Stewart, A.
  • Rowan, A.
  • Hiley, C.
  • Goldman, J.
  • Ahmed, A.
  • Taylor, M.
  • Choudhary, J.
  • Shaw, P.
  • Veeriah, R.
  • Czyzewska-Khan, J.
  • Johnson, D.
  • Laycock, J.
  • Hynds, R.
  • Werner Sunderland, M.
  • Reading, J.
  • Novelli, M.
  • Oukrif, D.
  • Janes, S.
  • Forster, M.
  • Ahmad, T.
  • Lee, S.M.
  • van Loo, P.
  • Ward, G.E.
  • Al-Bakir, M.
  • Carnell, D.
  • Mendes, R.
  • George, J.
  • Navani, N.
  • Papadatos-Pastos, D.
  • Scarci, M.
  • Gorman, P.
  • Lowe, H.
  • Ensell, L.
  • Moore, D.
  • MacKenzie, M.
  • Wilcox, M.
  • Bell, H.
  • Hackshaw, A.
  • Yenting, N.
  • Smith, S.
  • Gower, N.
  • Ottensmeier, C.
  • Chee, S.
  • Johnson, B.
  • Alzetani, A.
  • Shaw, E.
  • Lim, E.
  • De Sousa, P.
  • Tavares-Barbosa, M.
  • Nicholson, A.
  • Bowman, A.
  • Jordan, S.
  • Rice, A.
  • Raubenheimer, H.
  • Proli, C.
  • Cufari, M.E.
  • Ronquillo, J.C.
  • Kwayie, A.
  • Bhayani, H.
  • Hamilton, M.
  • Bakar, Y.
  • Mensah, M.
  • Ambrose, L.
  • Devaraj, A.
  • Buderi, S.
  • Finch, J.
  • Azcarate, L.
  • Chevan, H.
  • Green, S.
  • Mashinga, H.
  • Lau, K.
  • Sheaff, M.
  • Schmid, P.
  • Conibear, J.
  • Ezhil, V.
  • Prakesh, V.
  • Danson, S.
  • Bury, J.
  • Edwards, J.G. (0000-0002-7935-5327)
  • Hill, J.
  • Matthews, S.
  • Kitsanta, Y.
  • Suvarna, K.
  • Shackcloth, M.
  • Gosney, J.
  • Postmus, P.
  • Feeney, S.
  • Asante-Siaw, J.
  • Russell, P.
  • Light, T.
  • Horey, T.
  • Blyth, K.
  • Dick, C
  • Kirk, A.
  • Pule, M.
  • Marafioti, M.
  • Gore, M.
  • Larkin, J.
  • Turajlic, S.
  • Swanton, C.
  • Peggs, K.S.
  • Quezada, S.A.
Copyright, Publisher and Additional Information: © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0) .
Keywords: CTLA-4; Regulatory T cell depletion; Ipilimumab; Tremelimumab; Antibody-dependent cell-mediated cytotoxicity; Fc-gamma receptors; IgG subclass; Immune checkpoints; Tumor immunotherapy; Immune regulatory antibodies
Dates:
  • Accepted: 15 February 2018
  • Published (online): 22 March 2018
  • Published: 9 April 2018
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Sheffield Teaching Hospitals
Depositing User: Symplectic Sheffield
Date Deposited: 06 Feb 2019 14:48
Last Modified: 06 Feb 2019 14:48
Published Version: https://doi.org/10.1016/j.ccell.2018.02.010
Status: Published
Publisher: Elsevier
Refereed: Yes
Identification Number: https://doi.org/10.1016/j.ccell.2018.02.010
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