Manners, O orcid.org/0000-0001-7173-8908, Baquero-Perez, B and Whitehouse, A orcid.org/0000-0003-3866-7110 (2019) m⁶A: Widespread regulatory control in virus replication. BBA - Gene Regulatory Mechanisms, 1862 (3). pp. 370-381. ISSN 1874-9399
Abstract
N⁶-methyladenosine (m⁶A) is a highly pervasive and dynamic modification found on eukaryotic RNA. Despite the failure to comprehend the true regulatory potential of this epitranscriptomic mark for decades, our knowledge of m⁶A has rapidly expanded in recent years. The modification has now been functionally linked to all stages of mRNA metabolism and demonstrated to regulate a variety of biological processes. Furthermore, m6A has been identified on transcripts encoded by a wide range of viruses. Studies to investigate m⁶A function in viral-host interactions have highlighted distinct roles indicating widespread regulatory control over viral life cycles. As a result, unveiling the true influence of m⁶A modification could revolutionise our comprehension of the regulatory mechanisms controlling viral replication. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). | ||||
Keywords: | m⁶AViral replication; Epitranscriptomics; RNA modification; Post-transcriptional gene regulation; Virus-host interactions | ||||
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Institution: | The University of Leeds | ||||
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Molecular Biology (Leeds) | ||||
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Depositing User: | Symplectic Publications | ||||
Date Deposited: | 07 Nov 2018 15:20 | ||||
Last Modified: | 25 Jun 2023 21:35 | ||||
Status: | Published | ||||
Publisher: | Elsevier | ||||
Identification Number: | https://doi.org/10.1016/j.bbagrm.2018.10.015 |