Holmes, C., Hamer, M., Brown, C. et al. (7 more authors) (2017) Pellston MixturesProspective Aquatic Risk Assessment for Chemical Mixturesin Agricultural Landscapes. Environmental Toxicology and Chemistry , 37 (3). pp. 674-689. ISSN 0065-7727
Abstract
Environmental risk assessment of chemical mixtures is challenging because of the multitude of possible combinationsthat may occur. Aquatic risk from chemical mixtures in an agricultural landscape was evaluated prospectively in 2 exposurescenario case studies: at field scale for a program of 13 plant-protection products applied annually for 20 yr and at a watershedscale for a mixed land-use scenario over 30 yr with 12 plant-protection products and 2 veterinary pharmaceuticals used for beefcattle. Risk quotients were calculated from regulatory exposure models with typical real-world use patterns and regulatoryacceptable concentrations for individual chemicals. The results could differentiate situations when there was concern associatedwith single chemicals from those when concern was associated with a mixture (based on concentration addition) with no singlechemical triggering concern. Potential mixture risk was identified on 0.02 to 7.07% of the total days modeled, depending on thescenario, the taxa, and whether considering acute or chronic risk. Taxa at risk were influenced by receiving water bodycharacteristics along with chemical use profiles and associated properties. The present study demonstrates that a scenario-based approach can be used to determine whether mixtures of chemicals pose risks over and above any identified usingexisting approaches for single chemicals, how often and to what magnitude, and ultimately which mixtures (and dominantchemicals) cause greatest concern.
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | ||||
Keywords: | Risk assessment; Chemical mixture; Landscape; Agriculture; Exposure scenario | ||||
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Institution: | The University of Sheffield | ||||
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Animal and Plant Sciences (Sheffield) | ||||
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Depositing User: | Symplectic Sheffield | ||||
Date Deposited: | 31 May 2018 14:59 | ||||
Last Modified: | 31 May 2018 14:59 | ||||
Published Version: | https://doi.org/10.1002/etc.4049 | ||||
Status: | Published | ||||
Publisher: | Wiley | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1002/etc.4049 | ||||
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