Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model

Juel, H.B., Thomaides-Brears, H.B., Darton, T.C. orcid.org/0000-0003-2209-9956 et al. (12 more authors) (2018) Salmonella Typhi Bactericidal Antibodies Reduce Disease Severity but Do Not Protect against Typhoid Fever in a Controlled Human Infection Model. Frontiers in Immunology, 8. 1916.

Abstract

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Authors/Creators:
  • Juel, H.B.
  • Thomaides-Brears, H.B.
  • Darton, T.C. https://orcid.org/0000-0003-2209-9956
  • Jones, C.
  • Jones, E.
  • Shrestha, S.
  • Sie, R.
  • Eustace, A.
  • Galal, U.
  • Kurupati, P.
  • Van, T.T.
  • Thieu, N.T.V.
  • Baker, S.
  • Blohmke, C.J.
  • Pollard, A.J.
Copyright, Publisher and Additional Information: © 2018 Juel, Thomaides-Brears, Darton, Jones, Jones, Shrestha, Sie, Eustace, Galal, Kurupati, Van, Thieu, Baker, Blohmke and Pollard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: typhoid infection; bactericidal activity; human challenge model; Salmonella enterica Typhi; immune responses
Dates:
  • Published: 17 January 2018
  • Accepted: 14 December 2017
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Cardiovascular Science (Sheffield)
The University of Sheffield > Sheffield Teaching Hospitals
Depositing User: Symplectic Sheffield
Date Deposited: 05 Feb 2018 15:35
Last Modified: 05 Feb 2018 15:35
Published Version: https://doi.org/10.3389/fimmu.2017.01916
Status: Published
Publisher: Frontiers Media
Refereed: Yes
Identification Number: https://doi.org/10.3389/fimmu.2017.01916
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