Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM

Rawson, S orcid.org/0000-0002-2973-2630, Bisson, C, Hurdiss, DL et al. (6 more authors) (2018) Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. Proceedings of the National Academy of Sciences of the United States of America, 115 (8). pp. 1795-1800. ISSN 0027-8424

Abstract

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Authors/Creators:
Copyright, Publisher and Additional Information: © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Keywords: electron microscopy; structure-based drug design; histidine biosynthesis; IGPD; enzyme inhibition
Dates:
  • Published: 20 February 2018
  • Accepted: 9 January 2018
  • Published (online): 6 February 2018
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds)
The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Cryo EM, Image Processing (Leeds)
The University of Leeds > Faculty of Maths and Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds)
Funding Information:
FunderGrant number
MRCG1000567/1
Depositing User: Symplectic Publications
Date Deposited: 11 Jan 2018 10:30
Last Modified: 16 Mar 2018 10:51
Status: Published
Publisher: National Academy of Sciences
Identification Number: https://doi.org/10.1073/pnas.1708839115

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