A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile

Bailey, I, Gibson, GG, Plant, K et al. (2 more authors) (2011) A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile. PLoS ONE, 6 (2). e16703. ISSN 1932-6203

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Copyright, Publisher and Additional Information: © 2011, Bailey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Gene expression; Hepatocytes; RNA extraction; Drug metabolism; Bile; Microarrays; Enzyme metabolism; Xenobiotic metabolism
Dates:
  • Accepted: 27 December 2010
  • Published (online): 2 February 2011
  • Published: 2 February 2011
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds)
Depositing User: Symplectic Publications
Date Deposited: 22 May 2019 12:32
Last Modified: 22 May 2019 12:32
Status: Published
Publisher: Public Library of Science
Identification Number: https://doi.org/10.1371/journal.pone.0016703
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