Schroder, Sybrin P, van de Sande, Jasper W, Kallemeijn, Wouter W. et al. (13 more authors) (2017) Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines. Chemical Communications. pp. 1-5. ISSN 1364-548X
Abstract
Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of [small beta]-glucosidases and [small beta]-galactosidases.
Metadata
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Copyright, Publisher and Additional Information: | © 2017, The Author(s). | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
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Depositing User: | Pure (York) | ||||
Date Deposited: | 09 Nov 2017 14:19 | ||||
Last Modified: | 06 Dec 2023 12:08 | ||||
Published Version: | https://doi.org/10.1039/C7CC07730K | ||||
Status: | Published online | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1039/C7CC07730K |