Hernandez-Alava, M. and Pudney, S. (2017) Econometric modelling of multiple self-reports of health states: The switch from EQ-5D-3L to EQ-5D-5L in evaluating drug therapies for rheumatoid arthritis. Journal of Health Economics, 55. pp. 139-152. ISSN 0167-6296
Abstract
EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument describing health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but the consequences of this change are uncertain. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people with rheumatic disease, and use it to generate mappings between the alternative descriptive systems. We revisit a major cost-effectiveness study of drug therapies for rheumatoid arthritis, mapping the original EQ-5D-3L measure onto a 5L valuation basis. Working within a comprehensive, flexible econometric framework, we find that use of simpler restricted specifications can make very large changes to cost-effectiveness estimates with serious implications for decision-making.
Metadata
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Copyright, Publisher and Additional Information: | © 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | ||||
Keywords: | EQ-5D; Ordinal response; Copula; Mixture models; Rheumatoid arthritis; Mapping; Cost-effectiveness | ||||
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Institution: | The University of Sheffield | ||||
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research | ||||
Funding Information: |
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Depositing User: | Symplectic Sheffield | ||||
Date Deposited: | 26 Oct 2017 10:28 | ||||
Last Modified: | 03 Apr 2019 11:18 | ||||
Published Version: | https://doi.org/10.1016/j.jhealeco.2017.06.013 | ||||
Status: | Published | ||||
Publisher: | Elsevier | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1016/j.jhealeco.2017.06.013 | ||||
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