A novel Fluid-Solid-Growth-Transport (FSGT) framework for modelling the evolution of intracranial aneurysm disease

Computational models of intracranial aneurysm (IA) evolution do not explicitly represent endothelial cells (ECs). Here, we extend an IA Fluid-Solid-Growth framework to model Transport and to explicitly represent the morphology of the endothelium; we consider the competing influences of both cyclic deformation and wall shear stress to guide EC shape and alignment. We then establish a model which links EC morphology to EC permeability and the growth of the aneurysm. We envisage improved modelling of the role of the endothelium may help to differentiate between stable IAs and those likely to rupture.