Nikiphorou, E, Buch, MH orcid.org/0000-0002-8962-5642 and Hyrich, KL (2017) Biologics registers in RA: methodological aspects, current role and future applications. Nature Reviews Rheumatology, 13 (8). pp. 503-510. ISSN 1759-4790
Abstract
The beginning of the 21st century saw a biopharmaceutical revolution in the treatment of inflammatory rheumatic diseases, particularly rheumatoid arthritis. The fast-evolving use of biologic therapies highlighted the need to develop registers at national and international levels with the aim of collecting long-term data on patient outcomes. Over the past 15 years, many biologics registers have contributed a wealth of data and provided robust and reliable evidence on the use, effectiveness and safety of these therapies. The unavoidable challenges posed by the continuous introduction of new therapies, particularly with regard to understanding their long-term safety, highlights the importance of learning from experience with established biologic therapies. In this Perspectives article, the role of biologics registers in bridging the evidence gap between efficacy in clinical trials and real-world effectiveness is discussed, with a focus on methodological aspects of registers, their unique features and challenges and their role going forward.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Macmillan Publishers Limited, part of Springer Nature. This is an author produced version of a paper published in Nature Reviews Rheumatology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Biological therapy; Health care; Rheumatoid arthritis |
Dates: |
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Institution: | The University of Leeds |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Jun 2017 09:29 |
Last Modified: | 01 Dec 2017 01:39 |
Status: | Published |
Publisher: | Nature Publishing Group |
Identification Number: | https://doi.org/10.1038/nrrheum.2017.81 |