Adams, H., Baker, M., Hodson, H. et al. (1 more author) (2017) One-pot synthesis of 3-arylaminomaleimides from terminal alkynes and isocyanates. Tetrahedron Letters, 58 (17). pp. 1695-1698. ISSN 0040-4039
Abstract
The reaction of aryl acetylide anions with phenyl isocyanate and subsequent addition of a protonating agent such as ethanol affords good yields of 3-aminomaleimides, formed by the cyclization of one molecule of alkyne with two isocyanates. When the reaction is quenched with water instead, cyclopentadienone imines are formed as the major products.
Metadata
Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Elsevier. This is an author produced version of a paper subsequently published in Tetrahedron Letters. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | Acetylide; Alkyne; Isocyanate; Hydantoin; Heterocycle; Maleimide |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Apr 2017 15:02 |
Last Modified: | 12 Mar 2018 01:39 |
Published Version: | https://doi.org/10.1016/j.tetlet.2017.03.050 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | https://doi.org/10.1016/j.tetlet.2017.03.050 |
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