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Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity

Rolfe, Matthew, Thompson, Arthur, Hinton, Jay C. D., Kleanthous, Colin, WALKER, DANIEL, Moore, Geoffrey R. and James, Richard (2004) Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity. Journal of Bacteriology. pp. 866-869. ISSN 0021-9193

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Abstract

We report the transcriptional response of Escherichia coli MG1655 to damage induced by colicins E3 and E9, bacteriocins that kill cells through inactivation of the ribosome and degradation of chromosomal DNA, respectively. Colicin E9 strongly induced the LexA-regulated SOS response, while colicin E3 elicited a broad response that included the induction of cold shock genes, symptomatic of translational arrest. Colicin E3 also increased the transcription of cryptic prophage genes and other laterally acquired mobile elements. The transcriptional responses to both these toxins suggest mechanisms that may promote genetic diversity in E. coli populations, pointing to a more general role for colicins in adaptive bacterial physiology than has hitherto been realized.

Item Type: Article
Copyright, Publisher and Additional Information: Copyright © 2004, American Society for Microbiology.
Keywords: RNA HELICASE, IMMUNITY PROTEIN, GENE-EXPRESSION, LOW-TEMPERATURE, SHOCK, E9, INHIBITORS, STRESS, CSPA, HEAT
Academic Units: The University of York > Biology (York)
Depositing User: Christina Hudson
Date Deposited: 20 Feb 2006
Last Modified: 17 Oct 2013 14:27
Published Version: http://dx.doi.org/10.1128/JB.186.3.866-869.2004
Status: Published
Refereed: Yes
Related URLs:
URI: http://eprints.whiterose.ac.uk/id/eprint/1043

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