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Methodological bias in cluster randomised trials

Hahn, Seokyung, Puffer, Suezann, Torgerson, David J (orcid.org/0000-0002-1667-4275) and Watson, Judith (orcid.org/0000-0003-0694-3854) (2005) Methodological bias in cluster randomised trials. BMC Medical Research Methodology. ISSN 1471-2288

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Background: Cluster randomised trials can be susceptible to a range of methodological problems. These problems are not commonly recognised by many researchers. In this paper we discuss the issues that can lead to bias in cluster trials. Methods: We used a sample of cluster randomised trials from a recent review and from a systematic review of hip protectors. We compared the mean age of participants between intervention groups in a sample of 'good' cluster trials with a sample of potentially biased trials. We also compared the effect sizes, in a funnel plot, between hip protector trials that used individual randomisation compared with those that used cluster randomisation. Results: There is a tendency for cluster trials, with evidence methodological biases, to also show an age imbalance between treatment groups. In a funnel plot we show that all cluster trials show a large positive effect of hip protectors whilst individually randomised trials show a range of positive and negative effects, suggesting that cluster trials may be producing a biased estimate of effect. Conclusion: Methodological biases in the design and execution of cluster randomised trials is frequent. Some of these biases associated with the use of cluster designs can be avoided through careful attention to the design of cluster trials. Firstly, if possible, individual allocation should be used. Secondly, if cluster allocation is required, then ideally participants should be identified before random allocation of the clusters. Third, if prior identification is not possible, then an independent recruiter should be used to recruit participants.

Item Type: Article
Copyright, Publisher and Additional Information: © 2005 Hahn et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Age Factors,Cluster Analysis,Hip Fractures,Humans,Informed Consent,Patient Selection,Periodicals as Topic,Protective Devices,Randomized Controlled Trials as Topic,Refusal to Participate,Research Design,Sample Size,Selection Bias
Institution: The University of York
Academic Units: The University of York > Health Sciences (York)
Depositing User: Repository Officer
Date Deposited: 17 Feb 2006
Last Modified: 24 Jul 2016 00:10
Published Version: http://dx.doi.org/10.1186/1471-2288-5-10
Status: Published
Refereed: Yes
URI: http://eprints.whiterose.ac.uk/id/eprint/1031

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