Background: Although guidance on good research practice in health economic modelling is widely available, there is still a need for a simpler instructive resource which could guide a beginner modeller alongside modelling for the first time. Aim: To develop a Beginner’s Guide to be used as a hand-held guide contemporaneous to the model development process. Methods: A systematic review of best practice guidelines was used to construct a framework of steps undertaken during the model development process. Focused methods reviews supplemented this framework. Consensus was obtained amongst a group of model developers to review and finalise the content of the preliminary Beginner’s Guide. The final Beginner’s Guide was used to develop cost effectiveness models. Results: Thirty two best practice guidelines were data extracted, synthesised and critically evaluated to identify steps for model development which formed a framework for the Beginner’s Guide. Within five phases of model development, eight broad submethods were identified and nineteen methodological reviews were conducted to develop the content of the draft Beginner’s Guide. Two rounds of consensus agreement were undertaken to reach agreement on the final Beginner’s Guide. To assess fitness for purpose (ease of use and completeness), models were developed independently and by the researcher using the Beginner’s Guide. Conclusion: A combination of systematic review, methods reviews, consensus agreement and validation was used to construct a step-by-step Beginner’s Guide for developing decision analytical cost effectiveness models. The final Beginner’s Guide is a step-by-step resource to accompany the model development process from understanding the problem to be modelled, model conceptualisation, model implementation, and model checking through to reporting of the model results.
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)